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Related Experiment Videos

Deep scopulariopsosis: a case report and sensitivity studies.

A S Sekhon, D J Willans, J H Harvey

    Journal of Clinical Pathology
    |October 1, 1974
    PubMed
    Summary

    Scopulariopsis brevicaulis caused chronic inflammation of tendon sheaths. Griseofulvin and hamycin showed antifungal activity, while Lysobacter antibioticus inhibited fungal growth.

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    Area of Science:

    • Mycology
    • Infectious Diseases
    • Dermatology

    Background:

    • Chronic inflammation of tendon sheaths can be challenging to treat.
    • Fungal infections, though less common than bacterial, can cause persistent inflammation.

    Purpose of the Study:

    • To identify the causative agent of chronic granulomatous inflammation in a patient's tendon sheaths.
    • To evaluate the in vitro antifungal susceptibility of the isolated fungus to various agents.

    Main Methods:

    • Histopathological examination of excised tissue.
    • KOH and PAS staining.
    • Fungal culture and identification (Scopulariopsis brevicaulis).
    • In vitro antifungal susceptibility testing of isolated fungus.

    Main Results:

    • Histopathology revealed chronic granulomatous inflammation with fungal elements.
    • Scopulariopsis brevicaulis was identified as the causative agent.
    • Griseofulvin and hamycin demonstrated the most significant in vitro inhibition of fungal growth.
    • Lysobacter antibioticus (myxin antibiotic producer) strongly inhibited Scopulariopsis brevicaulis growth.

    Conclusions:

    • Scopulariopsis brevicaulis can cause chronic granulomatous inflammation of tendon sheaths.
    • Griseofulvin and hamycin show potential as therapeutic agents.
    • Lysobacter antibioticus exhibits potent antifungal activity against this isolate.

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