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Updated: Jan 8, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
Published on: August 19, 2025
Validation of a Mass Spectrometry-Based Proteomics Molecular Pathology Assay
Jessica R Chapman1, Jeeyeon Baik1, Oana Madalina Mereuta1
1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, USA.
Abstract:
Mass spectrometry-based proteomics has been applied to many fields and has made major contributions to our understanding of biology and medicine. Translation of this technology and assays to patient testing has been limited despite grand expectations. The amyloid protein identification by LC-MS test is one successful example of the adaptation of this technology by molecular and clinical pathology laboratories. Through the illustration of this assay, we will address some of these challenges and outline a process for validation and implementation of mass spectrometry-based proteomics in the molecular pathology laboratory.
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