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Updated: Jun 30, 2026
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
14.9K
Hydrogel Microneedle Array-Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of
Md Sharifuzzaman1, Gauri Hasabnis1, Sheikh Ahmed Abu Saleh1
1Chair for Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany.
Small (Weinheim an Der Bergstrasse, Germany)
|December 15, 2025
Summary
A novel microneedle dressing continuously monitors chronic wound biomarkers in interstitial fluid for personalized management. This theranostic system offers improved diagnostics and therapeutic delivery compared to surface sensors.
Area of Science:
- Biomaterials Science
- Medical Diagnostics
- Wound Care Technology
Background:
- Topical chronic wound dressings lack advanced sensing and therapeutic delivery capabilities due to surface-level interaction.
- Effective chronic wound management requires real-time monitoring of deep-tissue biochemical markers.
Purpose of the Study:
- To develop a theranostic hydrogel-forming microneedles (HFMNs) dressing system for continuous interstitial fluid (ISF) sampling.
- To enable high-fidelity diagnostics and active therapy for chronic wounds through microneedle technology.
Main Methods:
- Fabrication of HFMNs from polyvinyl alcohol/chitosan hydrogel with MXene.
- Integration of laser-scribed electrodes for multiplexed monitoring of seven wound biomarkers (glucose, uric acid, Na+, K+, Cl-, pH, temperature).
- In vitro cytocompatibility and antimicrobial testing, followed by in vivo studies in rat models.
Main Results:
- HFMNs demonstrated cytocompatibility and antimicrobial properties against E. coli and S. aureus.
- In vivo studies showed accelerated wound closure in rat models.
- The HFMN system accurately captured dynamic changes in wound ISF, outperforming conventional surface sensors.
Conclusions:
- The developed HFMN dressing system provides a robust platform for personalized chronic wound management.
- Directly linking deep-tissue biomarkers to wound status enables proactive and precise therapeutic interventions.
- This technology paves the way for advanced theranostic solutions in wound care.
