Related Experiment Video
Updated: Jan 8, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Sodium oxybate and acamprosate association for maintenance of alcohol abstinence: a case series
Fabio Caputo1, Martina Lombardi2, Caterina Trevisan2
1Centro Universitario per lo Studio ed il Trattamento delle Patologie Alcol-Correlate (PACC), Dipartimento di Medicina Traslazionale, Università degli Studi di Ferrara, Ferrara, Italy.
Background:
Disulfiram, acamprosate (ACM), naltrexone, and nalmefene are medications currently approved for the treatment of Alcohol Use Disorder (AUD). Baclofen and sodium oxybate (SO) have been approved for the treatment of AUD and alcohol withdrawal syndrome in France and Italy, respectively. However, concerning the effectiveness of combined therapies for AUD, data from the current literature are contrasting.
Aims:
To investigate the outcomes of combined therapy of SO and ACM for the maintenance of alcohol abstinence.
Methods:
A sample of 48 AUD patients consecutively enrolled and treated with SO (50-100 mg/kg of body weight, t.i.d.) plus ACM (666 mg three times daily; with dosage reduced in patients with body weight <60 kg) was observed for 12 weeks.
Results:
At the 3-month visit, continuous abstinence from alcohol was maintained by 34 patients (70.8%). Fifteen patients (31.3%) reported side effects like nausea, dizziness, and abdominal pain, with no significant differences between abstinent and not abstinent patients.
Conclusion:
SO plus ACM may be an effective and safe pharmacological combination for maintaining alcohol abstinence in AUD patients. Future ad hoc clinical trials are needed to test this therapeutic association for AUD treatment.
More Related Videos
09:29Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
05:40The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Drug Dependence
Drug Abuse and Addiction: Pharmacological Phenomena
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...