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  1. Home
  3. Association Of Inflammatory Markers And Hematological Inflammatory Indices In Predicting Pseudoexfoliation.
  1. Home
  3. Association Of Inflammatory Markers And Hematological Inflammatory Indices In Predicting Pseudoexfoliation.

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Association of inflammatory markers and hematological inflammatory indices in predicting pseudoexfoliation.

Harshitha C1, Chaitra M C1

  • 1Department of Ophthalmology, Sri Devaraj Urs Medical College, R.L. Jalappa Hospital, Kolar, Karnataka, India.

Bioinformation
|December 15, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Hematological indices like NLR and PLR are elevated in pseudoexfoliation syndrome (PEX), indicating inflammation. These simple blood tests may predict PEX and its systemic effects.

Keywords:
Neutrophil -Lymphocyte Ratio (NLR)Pseudoexfoliation syndromeRed Cell width distribution (RDW)inflammationsystemic immune-Inflammation index (SII)systemic markers

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Area of Science:

  • Ophthalmology
  • Immunology
  • Hematology

Background:

  • Pseudoexfoliation syndrome (PEX) is a common age-related ocular disorder.
  • PEX is associated with systemic inflammatory implications.

Purpose of the Study:

  • To investigate the role of various hematological indices in PEX.
  • To assess novel inflammatory markers like SII and SIRI in PEX patients.

Main Methods:

  • Cross-sectional study design.
  • Involved 195 PEX patients and 195 controls.
  • Analyzed neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and others.

Main Results:

  • All investigated hematological indices, including SII and SIRI, were significantly elevated in PEX patients (p < 0.05).
  • Red cell distribution width (RDW) was also higher in PEX patients.
  • Elevated RDW suggests increased oxidative stress and systemic involvement in PEX.

    • Conclusions:

    • Hematological indices, including novel markers like SII and SIRI, show significant elevation in PEX.
    • These accessible and cost-effective markers may serve as predictors of PEX-related inflammation.
    • Findings suggest a role for systemic inflammation in the pathophysiology of PEX.