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Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

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Verification of Normality in the Source Intensity Detection Rate for Batch Assay Using a Well-Type Ionization

Masato Takanashi¹, Isao Kuroda², Shinji Sugahara¹

¹Department of Radiology and Radiation Oncology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, JPN.

|December 15, 2025

Summary

This study confirms that the detection rate for TheraAgX100 brachytherapy seeds follows a normal distribution. This validates using the mean or median detection rate as the nominal value for batch assays, ensuring accurate source strength verification.

Keywords:

125i seed brachytherapy batch assay brachytherapy iodine-125 low-dose-rate brachytherapy prostate cancer single-seed assay well-type ionization chamber

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Medical Physics
Radiation Oncology
Quality Assurance

Background:

The American Association of Physicists in Medicine (AAPM) emphasizes source intensity verification.
Single-seed assays are challenging; batch assays using ionization chambers are an alternative.
Verification of TheraAgX100 seed detection rates using batch assays is not well-documented.

Purpose of the Study:

To verify the normality of detection rates for TheraAgX100 seeds.
To determine the appropriate nominal value for batch assay verification.
To ensure accurate quality assurance in brachytherapy.

Main Methods:

Collected detection rate data from 262 cases of TheraAgX100 seeds using a CRC-15R well-type ionization chamber.
Utilized Statistical Product and Service Solutions (SPSS) for data analysis.
Performed the Shapiro-Wilk test with a significance level of 0.05 to assess normality.

Main Results:

The Shapiro-Wilk test yielded a significance probability of 0.623.
The detection rates were confirmed to follow a normal distribution.
This validates the use of either the mean or median detection rate as the nominal value.

Conclusions:

The detection rate for TheraAgX100 seeds, when measured with the CRC-15R, is normally distributed.
The mean or median can be reliably used as the nominal value for batch assays.
This finding supports accurate source strength verification and quality assurance in 125I seed brachytherapy.