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To the homeRNAmax: Developing an Improved Blood Self-Collection and Stabilization Platform for Remote Transcriptomic

Madeleine Eakman1, Filip Stefanovic1, Jean Berthier1

  • 1Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

Biorxiv : the Preprint Server for Biology
|December 15, 2025
PubMed
Summary
This summary is machine-generated.

The homeRNAmax kit enables remote blood collection and immediate RNA stabilization for gene expression analysis. This user-friendly device ensures high-quality RNA yield, overcoming previous limitations for decentralized research.

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Area of Science:

  • Biotechnology
  • Genomics
  • Molecular Biology

Background:

  • Decentralizing human subjects research by enabling remote sample collection removes participation barriers.
  • Previous homeRNA kit stabilized RNA in self-collected blood using a custom tube.
  • Immediate RNA stabilization is crucial for downstream gene expression analysis.

Purpose of the Study:

  • Introduce homeRNAmax, an improved kit for remote blood RNA stabilization.
  • Enhance compatibility with commercial blood collection tubes and increase sample volume.
  • Characterize the spill-resistant mechanism of the homeRNA platform.

Main Methods:

  • Developed homeRNAmax kit compatible with BD Microtainer tubes.
  • Conducted a pilot study with 19 participants using homeRNAmax with Tasso+ device.
  • Utilized a theoretical model to analyze the spill-resistant fluidic feature.

Main Results:

  • homeRNAmax yielded high-quality RNA (mean RIN=7.8) and sufficient yield (mean=1.93 μg) for analysis.
  • Participants across the US successfully used the kit, with 17/19 finding it easy to use.
  • Theoretical model explained the spill-resistant feature based on pressure balance.

Conclusions:

  • homeRNAmax is a user-friendly and effective tool for remote blood RNA stabilization.
  • The improved design increases sample volume and compatibility with existing collection methods.
  • The spill-resistant feature ensures safe and reliable remote sample collection.