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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Transducer Mechanism: G Protein–Coupled Receptors01:30

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Related Experiment Video

Updated: Jan 8, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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Unlocking TRPM7 interactions: A database-driven quest.

Nicolas Jonckheere1, Lise Rodat-Despoix2, Isabelle Dhennin-Duthille2

  • 1Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille 59000, France.

Computational and Structural Biotechnology Journal
|December 15, 2025
PubMed
Summary
This summary is machine-generated.

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a dual function protein implicated in malignancies. This study identifies TRPM7 interactors, revealing potential therapeutic targets for digestive cancers like colorectal and pancreatic cancers.

Keywords:
BioGRID databaseGSEAProtein interactomeTRPM7

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Transient receptor potential cation channel subfamily M member 7 (TRPM7) is a protein with both channel and kinase functions.
  • TRPM7 is implicated in various diseases, including cancers, making it a potential therapeutic target.
  • Understanding TRPM7's interactions is crucial for elucidating disease mechanisms and developing novel treatments.

Purpose of the Study:

  • To identify and characterize the protein interactors of TRPM7.
  • To explore the role of TRPM7 in the context of digestive neoplasia.
  • To uncover potential therapeutic targets for precision medicine.

Main Methods:

  • Literature review of known TRPM7 interaction partners.
  • Analysis of public protein interaction databases (e.g., BioGRID).
  • Protein interaction modeling using computational tools (e.g., ProteinPrompt).

Main Results:

  • Identified 19 genes of interest as potential TRPM7 interactors.
  • These interactors are significantly associated with small GTPase pathways.
  • The identified pathways are relevant to digestive cancers, including colorectal and pancreatic cancers.

Conclusions:

  • The study provides an extended overview of potential TRPM7 interactors.
  • Further validation in cellular models is required to confirm these interactions.
  • This research offers insights into molecular mechanisms at the tumor cell membrane, paving the way for new therapeutic strategies.