Related Experiment Video
Updated: Jan 8, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Gentiooligosaccharide-Based Functional Syrup Modulates Lipid Metabolism to Attenuate High-Fat-Diet-Induced Obesity in
Zexi Li1, Tong Zhu1, Zhaofeng Li2,1,3
1School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Abstract:
The health-promoting effects of functional oligosaccharides have garnered significant attention. However, the physiological effects of gentiooligosaccharide, a novel functional oligosaccharide, remain largely unexplored. In this study, a gentiooligosaccharide-based syrup was synthesized using the crystalline glucose mother liquor as the substrate, and its potential to regulate glycolipid metabolism was evaluated through in vitro fermentation. Then, a high-fat-diet-induced obese mouse was employed to verify the effects. The results demonstrated that the syrup intervention significantly attenuated weight gain in the mice. Further analysis revealed that the syrup could regulate lipid metabolism, decrease ectopic fat deposition, and improve the morphology of liver and adipose tissues. Additionally, the syrup modulated obesity by affecting key metabolic pathways, including bile secretion and fatty acid decomposition, with these effects mediated by alterations in the intestinal microbiota composition. This research lays a solid groundwork for assessing the efficacy of gentiooligosaccharide and creating new syrup products based on functional oligosaccharides.
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
Glucose Absorption Into the Small Intestine
Oral Hypoglycemic Agents: Biguanides and Glitazones
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

