Commentary: Ultrasound Measurements of Skeletal Muscle Predict Chemotherapy Toxicity in Non-Small Cell Lung Cancer

We read with great interest the prospective multicenter study by Teng et al., which evaluated whether ultrasound-derived skeletal muscle indices could predict severe chemotherapy-related toxicity in patients with non-small cell lung cancer (NSCLC). We sincerely commend the authors for their innovative focus on a pragmatic, radiation-free tool that can be incorporated conveniently into routine oncology workflows. Their results-demonstrating that quadriceps cross-sectional area and muscle thickness independently predict grade 3-4 toxicities-offer clinically meaningful implications for early risk identification.