Association between cardiometabolic index and thyroid function: insights from NHANES

Area of Science:

• Endocrinology
• Metabolic Health
• Public Health

Background:

• The cardiometabolic index (CMI) is a composite measure reflecting metabolic and cardiovascular risk.
• Thyroid hormones play a crucial role in regulating metabolism.
• Understanding the interplay between CMI and thyroid function is essential for assessing cardiometabolic health.

Purpose of the Study:

• To investigate the association between the cardiometabolic index (CMI) and thyroid function.
• To explore the relationship between CMI and thyroid-related hormones and antibodies.

Main Methods:

• Cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012.
• Multivariate regression analyses were performed with CMI as the independent variable and thyroid hormones/antibodies as dependent variables.
• Subgroup analyses were conducted to assess the robustness of the findings.

Main Results:

• A total of 3,963 participants were analyzed.
• CMI showed a significant positive association with total triiodothyronine (TT3) and free triiodothyronine (FT3).
• Subgroup analyses indicated that gender, age, hypertension, and smoking influenced the CMI-TT3 relationship.

Conclusions:

• A positive association exists between higher CMI and increased TT3 and FT3 levels.
• These findings suggest a potential metabolic link between CMI and thyroid function.
• Further longitudinal studies are warranted to determine if thyroid function can predict cardiometabolic health outcomes.