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Mandibular Myofibroma With Impacted Teeth in a Child.
Junwei Wang1, Liying Chen1, Xuecai Yang1
1Department of Oral and Maxillofacial Surgery, Qingdao University Affiliated Qingdao Women and Children's Hospital.
The Journal of Craniofacial Surgery
|December 15, 2025
Summary
Mandibular myofibroma is a rare benign tumor in the jaw, often mistaken for other lesions. Early diagnosis through imaging and confirmed by histopathology is key to effective treatment and preventing recurrence.
Area of Science:
- Oral and Maxillofacial Pathology
- Skeletal Oncology
Background:
- Myofibroma is a benign mesenchymal tumor originating from myofibroblasts.
- While common in pediatric head and neck, mandibular involvement is rare and can be misdiagnosed.
- Differential diagnosis includes ameloblastoma and other bone lesions.
Purpose of the Study:
- To report a rare case of mandibular myofibroma in a pediatric patient.
- To highlight diagnostic challenges and confirm findings through histopathology and immunohistochemistry.
Main Methods:
- Case presentation of a 13-year-old female with mandibular swelling.
- Radiological assessment showing a well-circumscribed expansile bone lesion.
- Surgical excision and histopathological analysis including immunohistochemistry (SMA+, Desmin-, S-100-, Ki-67 low).
Main Results:
- The lesion was identified as a firm, gray-white mass.
- Histopathology revealed spindle-shaped cells in fascicles.
- Immunohistochemistry confirmed myofibroma, differentiating it from other tumors.
Conclusions:
- Mandibular myofibroma is a rare entity with radiological similarities to other jaw lesions.
- Accurate diagnosis requires histopathology and immunohistochemistry.
- Complete surgical resection is essential for favorable outcomes and to prevent recurrence.
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