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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Jan 8, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

Published on: September 1, 2018

"Reverse Looping for Nerve Repair: An Experimental Study on Retrograde Axonal Regeneration".

Leonardo D Lanzarin¹, Pedro A H Amaral², André L Espindola Junior²

¹Department of Orthopedics and Traumatology, Governador Celso Ramos Hospital, Florianopolis, SC, Brazil.

Plastic and Reconstructive Surgery

|December 15, 2025

Summary

Reverse nerve looping offers comparable outcomes to traditional nerve grafts for peripheral nerve repair. This innovative technique reduces coaptation sites, potentially improving functional recovery in selected cases.

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Last Updated: Jan 8, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

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Published on: September 1, 2018

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

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Published on: May 5, 2020

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration

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Published on: May 3, 2017

Area of Science:

Regenerative Medicine
Neurosurgery
Biomaterials Science

Background:

Peripheral nerve injuries with segmental loss pose significant reconstructive challenges.
Autologous nerve grafting, the current standard, involves two coaptation sites, increasing risks.
Retrograde axonal regeneration offers potential for novel reconstructive strategies.

Purpose of the Study:

To evaluate reverse nerve looping as an alternative to conventional nerve grafting.
To compare functional and histological outcomes of reverse nerve looping versus nerve grafting.
To assess the feasibility of a single coaptation site technique in peripheral nerve repair.

Main Methods:

Fifty-four rats underwent 15-mm median and ulnar nerve excision.
Nerve defects were reconstructed using autologous nerve grafts (two coaptations) or reverse nerve looping (one coaptation).
Functional recovery was assessed via grasp strength, electrophysiology, muscle weight, and histology.

Main Results:

Grasp strength recovery was comparable between groups at 30 weeks (61% Nerve Graft vs. 66% Reverse Nerve Loop).
Electrophysiology and muscle weight analyses showed similar recovery between the two surgical techniques.
Histological examination confirmed comparable axonal regeneration in both the Nerve Graft and Reverse Nerve Loop groups.

Conclusions:

Reverse nerve looping achieved functional and histological outcomes similar to autologous nerve grafting.
This technique successfully reduced the number of coaptation sites required for nerve repair.
Reverse nerve looping presents a promising alternative for specific peripheral nerve reconstruction scenarios.