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Unmasking tuberculosis triggered IgA nephropathy.
Amit Kumar1, Pooja Maheshwari2, Prasan Kumar Panda3
1Internal Medicine (ID Division), All India Institute of Medical Sciences-Rishikesh, Rishikesh, Uttarakhand, India.
BMJ Case Reports
|December 15, 2025
Summary
Tuberculosis-triggered IgA nephropathy (TB-IgAN) is a rare kidney disease. Early identification of TB-related renal involvement is crucial for managing IgA nephropathy.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Tuberculosis-triggered IgA nephropathy (TB-IgAN) is an uncommon renal complication of tuberculosis.
- It often presents with non-specific symptoms, leading to delayed diagnosis.
Purpose of the Study:
- To report a case of TB-IgAN in a young woman.
- To emphasize the importance of considering renal involvement in tuberculosis patients.
Main Methods:
- Case report of a woman in her 30s with symptoms of kidney disease and cough.
- Diagnostic workup including urinalysis, pulmonary evaluation for Mycobacterium tuberculosis (MTB), and kidney biopsy.
- Histopathological examination of the kidney biopsy.
Main Results:
- The patient was diagnosed with pulmonary tuberculosis and biopsy-confirmed IgA nephropathy (IgAN).
- The findings confirmed TB-IgAN as the cause of her rapidly progressive kidney disease.
- Kidney biopsy, though challenging with active MTB, was essential for diagnosis.
Conclusions:
- TB-IgAN requires a high index of suspicion in patients with tuberculosis and renal symptoms.
- Early detection of TB-related renal complications can significantly impact IgAN management.
- MTB can trigger immune-mediated renal diseases like IgAN, necessitating thorough evaluation.
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