C-H Amination of Heteroarenes Promoted by Cyclic Hypervalent Iodine(III) Reagents (cHIR)
Bin Wang1, Yunchen Jiang1, Yingqi Han1
1Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian District, Beijing 100084, P.R. China.
Abstract:
Herein, an efficient strategy for synthesizing novel cyclic hypervalent iodine(III) reagents (HIRs), featuring a transferable bis-sulfonimido group, has been developed. Based on a sulfonamide skeleton, these reagents are air- and moisture-stable, allowing for easy handling. Further studies have demonstrated that these reagents enable the direct C-H bond amination of diverse heteroaromatic compounds. Mechanistic studies suggest that the reaction proceeds via a radical pathway. This work advances research on cyclic HIRs and provides a practical strategy for the synthesis of valuable nitrogen-containing heteroaromatic compounds.
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