Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Shared and disease-specific human brain vascular signatures in Alzheimer's disease, frontotemporal dementia, and Huntington's disease.

bioRxiv : the preprint server for biology·2026

Same author

Association of chili leaf curl Vellanad virus with tomato leaf curl Joydebpur betasatellite in chili from Kerala, India.

Virusdisease·2026

Same author

Molecular characterization of begomoviruses infecting Sida acuta suggests a shared gene pool of tobacco curly shoot virus between weed and crop hosts.

Virology·2026

Same author

Chromatin remodeling by HIRA and FAS2 restricts geminivirus pathogenesis in plants.

Virology journal·2026

Same author

PIP<sub>2</sub> corrects an endothelial Piezo1 channelopathy.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Begomoviral pre-coat protein boosts potato virus X in mixed infection through interfering with antiviral RNAi response.

Virology journal·2025

Search research articles

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Published on: June 2, 2023

Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.

Zeynab Tabrizi¹, Xin Rui Lim², Supriya Chakraborty¹

¹Department of Biology, University of Miami, Miami, Florida, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 16, 2025

Summary

Systemic activation of Piezo1 improves cerebral blood flow and functional hyperemia in an Alzheimer's disease mouse model. This suggests Piezo1 is a potential therapeutic target for early cerebrovascular dysfunction in Alzheimer's disease.

Keywords:

Alzheimer's disease Piezo1 cerebral blood flow functional hyperemia neurovascular coupling

More Related Videos

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Published on: March 11, 2022

Piezo High Accuracy Surgical Osteal Removal PHASOR: A Technique for Improved Cranial Window Surgery in Mice

Piezo High Accuracy Surgical Osteal Removal PHASOR: A Technique for Improved Cranial Window Surgery in Mice

Published on: March 2, 2018

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Author Spotlight: Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model

Published on: June 2, 2023

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Published on: March 11, 2022

Piezo High Accuracy Surgical Osteal Removal PHASOR: A Technique for Improved Cranial Window Surgery in Mice

Piezo High Accuracy Surgical Osteal Removal PHASOR: A Technique for Improved Cranial Window Surgery in Mice

Published on: March 2, 2018

Area of Science:

Neuroscience
Vascular Biology
Pharmacology

Background:

Alzheimer's disease (AD) is characterized by reduced cerebral blood flow (CBF) and impaired functional hyperemia (FH).
These cerebrovascular deficits are early features contributing to AD progression.

Purpose of the Study:

To investigate the effect of systemic Piezo1 activation on cerebrovascular deficits in a mouse model of AD.
To determine if targeting the mechanosensitive ion channel Piezo1 can ameliorate AD-related vascular dysfunction.

Main Methods:

Utilized two-photon in vivo imaging and laser-speckle imaging in the 5xFAD mouse model of AD.
Assessed CBF, capillary stalling, and FH in response to whisker stimulation.
Administered the Piezo1 agonist Yoda1 systemically.

Main Results:

5xFAD mice exhibited increased capillary stalling and reduced CBF and FH compared to wild-type controls.
Yoda1 administration significantly reduced capillary stalls by approximately 65%.
Yoda1 treatment increased CBF and improved FH in 5xFAD mice, restoring responses to control levels.

Conclusions:

Piezo1 activation enhances microvascular flow and neurovascular coupling in the context of AD.
Piezo1 represents a promising therapeutic target for addressing early cerebrovascular dysfunction in Alzheimer's disease.