Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

5.3K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Periodontitis as an independent risk factor for cardiovascular disease: a systematic review and meta-analysis.

BMC oral health·2026
Same author

Evaluation of phloroglucinol for cytotoxic and anti-inflammatory effects in lung adenocarcinoma cells.

Journal, genetic engineering & biotechnology·2026
Same author

Comparative Evaluation of Microbial Adhesion and Surface Morphology of Bonded and Non-Bonded Resin-Based Composite Materials: A SEM and Microbiological Study.

International journal of dentistry·2026
Same author

De Winter Is Coming: A Rare ST-Segment Elevation Myocardial Infarction (STEMI) Equivalent in an Ironman Competitor.

Cureus·2026
Same author

Investigating salivary growth factor responses to tooth extraction in patients with type 2 diabetes: a prospective observational comparative study.

Frontiers in oral health·2026
Same author

Correction: Designed peptide-grafted hydrogels for human pluripotent stem cell culture and differentiation.

Journal of materials chemistry. B·2026

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

705

SFXN1 expression analysis in oral squamous cell carcinoma and its association with the PI3K-AKT-mTOR pathway and

Prabhu Manickam Natarajan1, Manoj Kumar Karuppan Perumal2, Sudhir Rama Varma1

  • 1Department of Clinical Sciences, College of Dentistry, Centre of Medical and Bio-Allied Health Sciences and Research, Ajman University, Ajman, United Arab Emirates.

Journal of Oral Biology and Craniofacial Research
|December 16, 2025
PubMed
Summary

Sideroflexin 1 (SFXN1) is upregulated in oral squamous cell carcinoma (OSCC) and linked to tumor progression. SFXN1 may offer therapeutic targets for OSCC, warranting further research.

Keywords:
BioinformaticsBiomarkerImmune infiltrationOSCCPI3K-AKT-mTORSFXN1

More Related Videos

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
06:38

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

6.8K
Three-Dimensional 3D Tumor Spheroid Invasion Assay
12:19

Three-Dimensional 3D Tumor Spheroid Invasion Assay

Published on: May 1, 2015

59.3K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

705
A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
06:38

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

6.8K
Three-Dimensional 3D Tumor Spheroid Invasion Assay
12:19

Three-Dimensional 3D Tumor Spheroid Invasion Assay

Published on: May 1, 2015

59.3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Oral squamous cell carcinoma (OSCC) presents aggressive progression and poor prognosis.
  • Sideroflexin 1 (SFXN1), a mitochondrial serine transporter, is investigated for its role in OSCC.
  • Integrated bioinformatic and experimental methods were employed.

Purpose of the Study:

  • To analyze SFXN1 expression, clinical relevance, and functional associations in OSCC.
  • To validate SFXN1 expression in OSCC cell lines.
  • To explore SFXN1's correlation with clinical parameters and immune infiltration.

Main Methods:

  • Analysis of TCGA pan-cancer cohorts for SFXN1 expression patterns.
  • Validation of SFXN1 levels in KB oral cancer cells.
  • Assessment of clinical correlations (grade, nodal status, survival) and immune cell infiltration.
  • Construction of protein-protein interaction networks and pathway enrichment analysis.
  • In vitro experimental validation.

Main Results:

  • SFXN1 was significantly overexpressed in head and neck squamous cell carcinoma and OSCC cell lines.
  • SFXN1 expression correlated with tumor grade and nodal metastasis.
  • Modest correlations were found between SFXN1 and immune cell populations, including CD4+ T cells.
  • Key hub genes (AKT1, BCL2, MTOR, CASP3) and pathways (PI3K-AKT-mTOR, p53) were identified.

Conclusions:

  • SFXN1 is involved in key cancer-related signaling pathways in OSCC.
  • SFXN1 demonstrates potential as a therapeutic target in OSCC.
  • Further investigation is required to elucidate SFXN1's precise role and therapeutic utility.