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Biomimetic Mineralized Hydrogels for Bone Regeneration
Mingming Zhao1,2, Xiaonong Zhang1, Chunsheng Xiao1,2
1State Key Laboratory of Polymer Science and Technology, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|December 16, 2025
Summary
Biomimetic mineralized hydrogels mimic natural bone formation for tissue engineering. This review explores their design, applications in bone regeneration, and future clinical translation potential.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomineralization
Background:
- Bone mineralization is a complex biological process crucial for bone's structure and function.
- Biomimetic mineralized hydrogels are engineered materials inspired by natural bone biomineralization.
- These hydrogels show promise for bone regeneration applications.
Purpose of the Study:
- To systematically review recent advancements in biomimetic mineralized hydrogels for bone regeneration.
- To highlight innovative strategies in hydrogel design and their functional mimicry.
- To critically examine therapeutic applications and future directions.
Main Methods:
- Overview of natural biomineralization principles.
- Summary of strategies for constructing heterogeneous and homogeneous biomimetic mineralized hydrogels.
- Critical analysis of therapeutic applications and challenges.
Main Results:
- Innovative hydrogel designs emphasize structural and functional mimicry of bone.
- Applications include bone defect repair, osteochondral regeneration, and osteoporotic bone repair.
- Identified challenges and future research directions for clinical translation.
Conclusions:
- Biomimetic mineralized hydrogels offer a promising platform for bone regeneration.
- Further research is needed to address challenges and advance clinical translation.
- These engineered materials hold potential for treating various bone-related diseases.
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