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Updated: Jan 8, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Cu-Catalyzed Highly Selective Ritter-Type Reaction of Enaminonitriles with Cycloketoxime Esters: A Direct Route to
Farrukh Sajjad1, Jiaqi Zhao2,3, Ling Zheng4
1Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China.
Abstract:
Significant progress has been made in recent years in Ritter-type reactions, particularly in developing diverse pathways for carbocation generation. However, most existing methods rely on stoichiometric oxidants or expensive reagents and are limited in nitrile scope. Herein, we report a highly selective Ritter-type reaction between enaminonitriles and oxime esters. This method provides efficient access to diversely functionalized, sterically congested α-tertiary amines (ATAs) under mild conditions with excellent selectivity, addressing key limitations of previous approaches.
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