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Myokines in Aging: A Multi-Organ Network Perspective.

Mei Xue1, Chengcheng Liao1, Yige Liu1

  • 1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & Engineering Research Center of Oral Translational Medicine, Ministry of Education, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.

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Summary
This summary is machine-generated.

Exercise training activates skeletal muscle to release myokines, which combat aging across multiple body systems. Harnessing these muscle-derived factors offers potential for healthy aging therapies.

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Area of Science:

  • Exercise physiology and aging research
  • Molecular biology of myokines
  • Systems biology of aging

Background:

  • Exercise is a potent anti-aging strategy counteracting age-related functional decline.
  • Skeletal muscle acts as a secretory organ, releasing myokines and extracellular vesicles.
  • These muscle-derived factors mediate inter-organ communication, contributing to exercise's systemic benefits.

Purpose of the Study:

  • To review how myokine networks counteract aging across major physiological systems.
  • To explore the modulation of aging processes like inflammation and metabolic dysregulation by myokines.
  • To discuss the influence of sex and age on myokine function and their translational potential.

Main Methods:

  • Literature review synthesizing current knowledge on myokines and aging.
  • Analysis of myokine networks' roles in metabolic, cardiovascular, musculoskeletal, nervous, and immune systems.
  • Examination of conserved signaling pathways modulated by myokines.

Main Results:

  • Myokines counteract aging by modulating chronic inflammation, metabolic dysregulation, and tissue homeostasis.
  • Diverse myokines converge on conserved signaling hubs for integrated protective effects.
  • Sex and age significantly influence myokine action and efficacy.

Conclusions:

  • Myokine networks are crucial for the systemic benefits of exercise in promoting healthy aging.
  • Personalized exercise and engineered myokine therapies show promise for clinical application.
  • Understanding myokine signaling is key to developing interventions against age-related decline.