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Exploring the Association of Campylobacter jejuni with inflammatory bowel diseases: insight from a clinical study
Nisreen Jawad Kadhim1, Fadhl ALzamili2, Riadh Hnewa3
1DEPARTMENT OF MICROBIOLOGY, COLLEGE OF MEDICINE, WARITH AL-ANBIYAA UNIVERSITY, KARBALA, IRAQ.
Objective:
Aim: To demonstrate a possible association between Campylobacter jejuni and inflammatory bowel disease Iraqi patients.
Patients And Methods:
Materials and methods: The study involved two groups. The inflammatory bowel disease patient group consisted of 90 participants. This group was further classified into two subgroups: Crohn's disease (n) and Ulcerative colitis (n). The control group consisted of 90 healthy participants who had no history of inflammatory bowel disease. Age and gender distributions in inflammatory bowel disease patient and control groups were computed. The association between inflammatory bowel disease and C. jejuni was determined by identifying the bacterial infection using various detection methods, including culturing, biochemical tests and real-time PCR (Polymerase chain reaction). The association was further assessed by comparing the symptoms of IBD patients and C. jejuni positive samples.
Results:
Results: Finding of the conventional identification showed 5% prevalence of C. jejuni among inflammatory bowel disease patients whereas the real-time Polymerase chain reaction. Results showed significantly higher prevalence. Based on real-time Polymerase chain reaction. Results, a significant association was found between C. jejuni infection with inflammatory bowel disease and Crohn's disease patients (P-value≤0.001).
Conclusion:
Conclusions: No significant differences observed in detection of inflammatory bowel disease and Crohn's disease using conventional and molecular methods. The study provides valuable insights into a possible association between C. jejuni and inflammatory bowel disease.
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