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Downregulation of TMTC4 expression is associated with improved prognosis in osteosarcoma

Zihan Li1, Yihao Tian2

  • 1China Medical University, China.

The Journal of International Medical Research
|December 16, 2025
PubMed

Insights

Transmembrane and tetratricopeptide repeat containing 4 (TMTC4) is newly identified in osteosarcoma. Low TMTC4 expression correlates with better prognosis and reduced tumor cell proliferation in osteosarcoma patients.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Osteosarcoma is the most common primary bone tumor.
  • The role of transmembrane and tetratricopeptide repeat containing 4 (TMTC4) in osteosarcoma remains uninvestigated.

Purpose of the Study:

  • To investigate the prognostic significance of TMTC4 in osteosarcoma.
  • To analyze the expression and functional impact of TMTC4 in osteosarcoma.

Main Methods:

  • Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were utilized.
  • Expression analysis, survival analysis, enrichment analysis, and methylation analysis were performed.
  • Polymerase chain reaction (PCR) and cell counting kit-8 assays assessed TMTC4 expression and cell proliferation.

Main Results:

  • TMTC4 was identified as a downregulated gene in osteosarcoma.
  • Low TMTC4 expression was associated with a higher survival rate in osteosarcoma patients.
  • Increased TMTC4 expression and methylation were observed in osteosarcoma cells; inhibiting TMTC4 reduced cell proliferation.

Conclusions:

  • TMTC4 serves as a potential prognostic biomarker for osteosarcoma.
  • Low TMTC4 expression indicates an improved prognosis in osteosarcoma.
Keywords:
Osteosarcomabioinformatics analysisbiomarkersprognosistransmembrane and tetratricopeptide repeat containing 4

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