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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Engineered Plant-Derived Extracellular Vesicles as Targeted Drug Carriers in Cancer Therapy.

Su Jin Kang^1,2, Won Jong Rhee^1,2,3

¹Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

ACS Applied Bio Materials

|December 17, 2025

Summary

Plant-derived extracellular vesicles (EVs) from black soybeans were engineered to deliver doxorubicin (Dox) chemotherapy. These targeted EVs show promise for effective breast cancer treatment with reduced side effects.

Keywords:

black soybean-derived extracellular vesicles cancer therapy drug delivery extracellular vesicles plant-derived extracellular vesicles

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Preparation of Exosomes for siRNA Delivery to Cancer Cells

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Published on: December 5, 2018

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Breast cancer chemotherapy faces challenges like poor drug targeting, low bioavailability, and systemic toxicity.
Extracellular vesicles (EVs) are promising drug delivery systems due to biocompatibility and cargo capacity.
Plant-derived EVs offer advantages like low immunogenicity and scalability for clinical use.

Purpose of the Study:

To develop a plant-derived EV-based drug delivery platform for targeted breast cancer chemotherapy.
To engineer black soybean-derived EVs (Blex) for enhanced drug loading and tumor specificity.
To evaluate the efficacy of engineered EVs in vitro and in vivo.

Main Methods:

High yield purification of black soybean-derived EVs (Blex).
Loading of doxorubicin (Dox) into Blex via passive diffusion.
Surface engineering of Blex with cyclic RGD (cRGD) peptide for cancer cell targeting.
In vitro cytotoxicity assays and in vivo tumor reduction studies.

Main Results:

Successfully purified and loaded Blex with doxorubicin (Blex(Dox)).
Engineered Blex(Dox) with cRGD (Blex(Dox)_cRGD) showed enhanced cellular uptake and cytotoxicity against breast cancer cells.
Blex(Dox)_cRGD demonstrated significant tumor reduction in vivo with minimized systemic toxicity.

Conclusions:

Plant-derived EVs provide a scalable and biocompatible platform for targeted chemotherapy.
Combining drug loading with surface engineering of EVs enhances therapeutic efficacy for breast cancer.
This strategy offers a foundation for developing next-generation nanomedicines for solid tumors.