Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

14.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.0K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.5K
3.5K
Survival Tree01:19

Survival Tree

369
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
 Building a Survival Tree
Constructing a...
369
RNA Editing02:23

RNA Editing

9.7K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.7K
Censoring Survival Data01:09

Censoring Survival Data

502
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
502
CRISPR01:59

CRISPR

57.4K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
57.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetic Approach for Assessing Absolute Hydrogen Potential (pH<sub>abs</sub>) across Diverse Solvents.

The journal of physical chemistry. A·2026
Same author

Bronchovascular texture pattern on quantitative CT reveals airway and vascular remodeling in post-COVID-19 Lungs.

Respiratory research·2026
Same author

Algal δ<sup>13</sup>C reveals climate changes during the Cambrian Explosion.

Nature communications·2026
Same author

Insights into the effects of gut microbiota and circulating metabolites on oral cancer: Mendelian randomization analysis and clinical validation.

Frontiers in nutrition·2026
Same author

Repetitive transcranial magnetic stimulation is associated with improved functional recovery and time-dependent changes in apoptosis-related execution-phase markers after spinal cord injury.

Scientific reports·2026
Same author

Access-controlled imaging via structured single-pixel illumination.

Optics letters·2026
Same journal

Leveraging Vulnerabilities in Temporal Graph Neural Networks via Strategic High-Impact Assaults.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2026
Same journal

MUSE: A Multi-slice Joint Analysis Method for Spatial Transcriptomics Experiments.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2026
Same journal

Enhanced Privacy Bound for Shuffle Model with Personalized Privacy.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2025
Same journal

Continually-Adaptive Representation Learning Framework for Time-Sensitive Healthcare Applications.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2025
Same journal

Causality-Aware Spatiotemporal Graph Neural Networks for Spatiotemporal Time Series Imputation.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2025
Same journal

HypMix: Hyperbolic Representation Learning for Graphs with Mixed Hierarchical and Non-hierarchical Structures.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management·2025
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

986

Backdoor in Seconds: Unlocking Vulnerabilities in Large Pre-trained Models via Model Editing.

Dongliang Guo1, Mengxuan Hu1, Zihan Guan1

  • 1University of Virginia, Charlottesville, Virginia, USA.

Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management
|December 17, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed EDT, an efficient, data-free, and training-free backdoor attack method for large pre-trained models. This novel approach addresses challenges in attacking complex AI systems without needing training data or model retraining.

Keywords:
Large Pre-trained ModelModel EditingSafety

More Related Videos

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.2K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.2K

Related Experiment Videos

Last Updated: Jan 8, 2026

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

986
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.2K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.2K

Area of Science:

  • Artificial Intelligence
  • Machine Learning Security
  • Computer Vision

Background:

  • Large pre-trained models (e.g., ViT) are powerful but vulnerable to backdoor attacks.
  • Existing attacks require access to training data and significant computational resources, posing challenges for large models.

Purpose of the Study:

  • To investigate the unique challenges of backdoor attacks on large pre-trained models.
  • To develop an effective and feasible backdoor attack method suitable for these models.

Main Methods:

  • Introduced EDT (Efficient, Data-free, Training-free), a novel backdoor attack method.
  • EDT utilizes model editing techniques by injecting a lightweight codebook to modify model behavior without data poisoning or retraining.

Main Results:

  • Demonstrated the effectiveness of EDT across various pre-trained models (ViT, CLIP, BLIP, stable diffusion).
  • Validated the attack's success on diverse downstream tasks like image classification, captioning, and generation.

Conclusions:

  • EDT presents a viable solution for backdoor attacks on large pre-trained models, overcoming previous limitations.
  • The method offers a practical approach to assessing the vulnerability of complex AI systems.