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Reading Between the Striatal Lines: Magnetic Resonance Imaging Insights Into Huntington Disease

Robert Boothe1, David J Houghton2,3, James Milburn1,3

  • 1Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Ochsner Journal
|December 17, 2025
PubMed
Abstract

No abstract available in PubMed .

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...