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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Study on the effect of body size on24Na activity-based neutron dose assessment
Xu Xu1, Botao Hu1, Jingwei Yue1
1Beijing Institute of Radiation Medicine, Beijing 100850, People's Republic of China.
Abstract:
Neutron dose assessment in radiation accidents relies on measuring induced2⁴Na activity via the23Na(n,γ)2⁴Na reaction. However, the effect of body size on neutron moderation, gamma self-absorption, and organ distribution-remains poorly quantified, with conflicting literature reports. To systematically evaluate the body size effect on neutron absorbed dose and2⁴Na yield, four human voxel phantoms of different body sizes (5-, 10-, 15-, and 38 year-old individuals) were irradiated in MCNP simulations with2⁵2Cf and 28 monoenergetic neutron sources (10-9-20 MeV) under six geometries. The neutron absorbed dose, induced2⁴Na activity per unit mass, and the conversion coefficients between24Na activity per unit mass and neutron absorbed dose were calculated. The results show that body size significantly affects the neutron dose. When the human body is irradiated with2⁵2Cf neutrons under different irradiation geometries, the conversion coefficients between2⁴Na activity per unit mass and neutron absorbed dose are at least 48.3% larger in adults than in 5 year-old children. When the human body is irradiated with monoenergetic neutrons under isotropic irradiation geometry, these conversion coefficients decrease with increasing body size for neutron energies <0.1 MeV, and increase with increasing body size for neutron energies >0.1 MeV. For 10-9MeV neutron irradiation, the coefficient for adults is 26.5% smaller than that of 5 year-old children. Conversely, for 20 MeV neutron irradiation, the coefficient for adults is 114.2% larger than that for 5 year-old children.
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