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Updated: Jan 8, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
Clinical and mechanistic insights into Brucella and viral co-infection
1State Key Laboratory of Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; College of Veterinary Medicine, Lanzhou University, Lanzhou 730046, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China.
Abstract:
Co-infection of Brucella and viruses represents an emerging clinical and epidemiological challenge. Recent evidence reveals that Brucella-viral co-infections are characterized by atypical clinical manifestations and increased diagnostic complexity. These dual infections involve intricate pathogen-host and pathogen-pathogen interactions: viruses enhance Brucella susceptibility by subverting innate and adaptive immune responses, while Brucella compromises host immunity to create a permissive microenvironment for viral persistence. Furthermore, co-infection synergistically exacerbates tissue damage, elevating disease severity. This review summarizes recently reported cases of Brucella-virus co-infections and their pathogenic mechanisms, aiming to advance our understanding of co-infection dynamics and provide foundational insights for elucidating pathogenesis and developing novel diagnostic and therapeutic approaches.
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