Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dopaminergic and perfusion modulation in non-fluent variant primary progressive aphasia following iTBS: A case report.

Asian journal of psychiatry·2026

Same author

Distinct Genetic Alterations Drive Cushing Disease Versus Silent Corticotroph Adenomas.

The Journal of clinical endocrinology and metabolism·2026

Same author

Delusional Pseudotranssexualism Associated With Exogenous Estrogen in Schizoaffective Disorder: A Case Report.

Journal of clinical psychopharmacology·2026

Same author

The role of alcohol metabolizing gene in patients with alcohol use disorder and heroin use disorder in the Taiwan Han Chinese population.

Progress in neuro-psychopharmacology & biological psychiatry·2026

Same author

Brexpiprazole-Induced Pisa Syndrome in a Patient With Dementia With Lewy Bodies.

American journal of therapeutics·2026

Same author

Complete Acid-Based Hydrolysis Assay for Carbohydrate Quantification in Seaweed: A Species-Specific Optimized Approach.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Transplantation tolerance versus immune evasion: Mechanistic divergences and therapeutic frontiers for islet cell replacement.

Cell reports. Medicine·2026

Same journal

Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer.

Cell reports. Medicine·2026

Same journal

Targeted DNA triplex-forming oligonucleotide liposome for pulmonary fibrosis gene therapy.

Cell reports. Medicine·2026

Same journal

Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults.

Cell reports. Medicine·2026

Same journal

Targeting cytokine-like protein FAM3D alleviates atherosclerosis.

Cell reports. Medicine·2026

Same journal

High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial.

Cell reports. Medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 8, 2026

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Contrastive learning enhances fairness in pathology artificial intelligence systems.

Shih-Yen Lin¹, Pei-Chen Tsai², Fang-Yi Su²

¹Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

Cell Reports. Medicine

|December 17, 2025

Summary

This summary is machine-generated.

AI bias in cancer diagnosis is reduced by FAIR-Path, a new framework. This AI fairness tool significantly lowers performance gaps in pathology evaluations across diverse patient groups.

Keywords:

AI algorithmic bias artificial intelligence bias mitigation cancer diagnosis contrastive learning deep learning fairness pathology weakly supervised learning

More Related Videos

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jan 8, 2026

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Author Spotlight: AI-Driven Trypanosome Species Detection from Microscopic Images

Published on: October 27, 2023

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Area of Science:

Medical Artificial Intelligence
Computational Pathology
Health Equity

Background:

AI-powered pathology systems show promise for cancer diagnosis.
Existing AI models often display biases against underrepresented populations due to limited training data diversity.

Purpose of the Study:

To introduce the Fairness-aware Artificial Intelligence Review for Pathology (FAIR-Path) framework.
To mitigate demographic biases in AI-based pathology evaluation systems.
To address fairness challenges in AI-driven medical diagnostics.

Main Methods:

Utilized contrastive learning and weakly supervised machine learning.
Conducted a pan-cancer AI fairness analysis across 20 cancer types.
Performed external validation across 15 independent cohorts.

Main Results:

Identified significant performance disparities in 29.3% of diagnostic tasks across race, gender, and age groups.
FAIR-Path mitigated 88.5% of identified disparities.
External validation demonstrated a 91.1% reduction in performance gaps.

Conclusions:

Variations in somatic mutation prevalence contribute to AI performance disparities.
FAIR-Path offers a robust framework for mitigating bias in medical AI.
This approach advances fairness in AI-powered pathology and cancer diagnosis.