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Related Experiment Video

Updated: Jun 17, 2026

An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
10:34

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In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons.

Claire J Millett1, James J Shaver1, Bernadette Bracken1

  • 1Kallyope, 430 East 29(th) Street, New York, NY 10016, USA.

Cell
|December 17, 2025
PubMed
Summary

Researchers profiled enteric neurons (ENs) to understand their role in gut function and disease. This study reveals cell type-specific functions and conservation between mouse and human ENs, aiding drug discovery for GI disorders.

Keywords:
enteric nervous systementeric neurongastrointestinal motilitygut braingut-brain axismouse human translationneuroimmunesatietysecretory functionsingle-nuclei sequencing

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Genomics

Background:

  • Enteric neurons (ENs) coordinate gastrointestinal (GI) functions but remain poorly understood at the molecular and circuit levels.
  • Dysfunction of ENs is implicated in various GI diseases, highlighting their therapeutic potential.

Purpose of the Study:

  • To comprehensively profile enteric neurons using modern neuroscience techniques.
  • To identify cell type- and region-specific functions of ENs in modulating GI physiology.
  • To assess the conservation of EN subsets between mice and humans for translational drug discovery.

Main Methods:

  • Single-nuclei sequencing for transcriptional profiling.
  • Chemogenetics and circuit tracing for functional analysis.
  • Pharmacological studies to investigate EN modulation of GI functions.

Main Results:

  • Detailed transcriptional and functional profiles of diverse EN populations.
  • Resolution of EN roles in regulating GI motility, secretion, food intake, and inflammation.
  • Identification of conserved and divergent features between mouse and human EN subsets.

Conclusions:

  • This work provides critical insights into EN cell type- and region-specific functions relevant to GI diseases.
  • Establishes a methodological foundation for in vivo investigation of ENs.
  • Highlights translational opportunities and challenges for targeting ENs in drug discovery.