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Published on: October 12, 2015
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Enhancing creatinine detection: Innovative biosensors for monitoring kidney function
Mohammad Mahdi Heidari1, Sepideh Shadravan2, Samira Jafarisis3
1Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 17, 2025
Summary
Nanomaterial-based biosensors offer a sensitive and rapid method for detecting creatinine, a key indicator of kidney function. This technology enhances early diagnosis and management of kidney diseases.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Creatinine is a vital biomarker for assessing renal function.
- Early and accurate detection of creatinine is essential for managing kidney diseases.
- Traditional methods for creatinine detection can be time-consuming and lack sensitivity.
Purpose of the Study:
- To explore the potential of nanomaterial-based biosensors for enhanced creatinine detection.
- To review various nanomaterials and their application in biosensing for kidney function assessment.
- To discuss the integration of these biosensors into wearable technologies for continuous monitoring.
Main Methods:
- Review of nanomaterials (carbon-based, metal nanoparticles, quantum dots) for biosensing.
- Analysis of electrochemical properties and biocompatibility of nanomaterials.
- Discussion of biosensor integration with wearable devices.
Main Results:
- Nanomaterials offer improved sensitivity, specificity, and rapid response times for creatinine detection.
- Enhanced surface area and reactivity of nanomaterials lead to lower detection limits.
- Wearable biosensors facilitate real-time, continuous monitoring of kidney health.
Conclusions:
- Nanomaterial-based biosensors represent a significant advancement in kidney disease diagnostics.
- These biosensors improve diagnostic accuracy and facilitate timely interventions.
- The technology holds promise for personalized medicine and reducing the burden of chronic kidney diseases.
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