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Electrochemical biosensors for lactoferrin.

Sajad Alavimanesh¹, Asma Vafadar², Setayesh Jannati²

¹Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|December 17, 2025

Summary

Lactoferrin (Lf) detection is vital for health and food safety. Electrochemical biosensors offer a rapid, sensitive, and cost-effective alternative to traditional methods for Lf analysis.

Keywords:

Biomarker Biosensors Electrochemical Lactoferrin

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Biosensing Technology

Background:

Lactoferrin (Lf) is a key glycoprotein involved in immune defense, iron regulation, and antimicrobial functions.
Lf serves as a critical biomarker for infections, inflammatory conditions, and various cancers.
Current detection methods like ELISA are sensitive but expensive and time-consuming.

Purpose of the Study:

To review the principles and recent advancements in electrochemical biosensors for lactoferrin detection.
To highlight the advantages of electrochemical biosensors over traditional Lf detection techniques.
To discuss the potential applications of these biosensors in clinical diagnostics and food safety.

Main Methods:

Exploration of nanomaterial-based electrode modifications for enhanced sensitivity.
Integration of biomolecular recognition elements for specific Lf targeting.
Analysis of electrochemical techniques for signal transduction and quantification.

Main Results:

Electrochemical biosensors demonstrate rapid response times and high sensitivity for Lf detection.
These biosensors offer portability and cost-effectiveness compared to conventional assays.
Advancements in materials science and biorecognition have significantly improved Lf sensing capabilities.

Conclusions:

Electrochemical biosensors represent a promising technology for accurate and efficient lactoferrin detection.
Their characteristics make them suitable for point-of-care diagnostics and real-time food safety monitoring.
Further research can optimize these biosensors for broader clinical and industrial implementation.