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Published on: May 21, 2019
Visible-Light-Promoted Iron-Catalyzed Amidation/Cyclization of Arylacrylamides with Dioxazolones
Yan Du1, Shuxin Liang1, Yi Wang1
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
None:
A visible-light-promoted and simple iron salt-catalyzed cascade amidation/cyclization of N-aryl acrylamides with dioxazolones was developed. The reaction proceeds under photosensitizer-free conditions and features satisfactory to good yields, broad functional group tolerance, and an easy operation procedure. Mechanistic studies revealed that the reaction proceeded via an iron-nitrene intermediate. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chemistry.
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