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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
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Partial hydatidiform mole coexists with a living fetus: a case report
Mohadeseh Karimi1, Anahita Alizadeh2
1Department of Pathology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. mohadesehkarimi2318@gmail.com.
Journal of Medical Case Reports
|December 17, 2025
Summary
Partial molar pregnancy, a rare condition, can coexist with a live fetus, posing risks to the neonate. Early diagnosis and close monitoring are crucial for managing this challenging pregnancy complication.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
- Maternal-Fetal Medicine
Background:
- Hydatidiform mole is a benign gestational trophoblastic disease (GTD), with partial molar pregnancy often presenting as miscarriage.
- Coexistence of partial molar pregnancy with a viable fetus is exceptionally rare.
Purpose of the Study:
- To present a case of partial molar pregnancy with a coexisting viable fetus.
- To highlight the diagnostic challenges and management considerations for this rare obstetric condition.
Main Methods:
- A case of normal vaginal delivery of a deceased fetus and placenta was investigated.
- Microscopic examination of placental tissue revealed features consistent with partial molar pregnancy, including hydropic villi and trophoblastic proliferation.
Main Results:
- The placenta showed characteristic signs of partial molar pregnancy.
- The fetus was compatible with 5-6 lunar months of gestation and had no gross anomalies.
Conclusions:
- Partial molar pregnancy is associated with a triploid karyotype and potential for malignant transformation (invasive mole or choriocarcinoma).
- The coexistence of molar pregnancy with a live fetus presents significant management challenges and increases risks for neonatal morbidity and mortality.
- Close maternal and fetal surveillance is recommended, though optimal management strategies require further investigation.
