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A rare case of multifocal prostatic blue nevus: a case report
Mahmoud Reza Kalantari1, Mohammad Aslzare2, Mohadeseh Karimi3
1Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Introduction And Importance:
Prostatic blue nevus (PBN) is an exceptionally rare benign melanocytic lesion of the prostate, usually discovered incidentally.
Case Presentation:
A 59-year-old Iranian male in otherwise good health presented to a urology clinic with an elevated PSA of 5.8 and obstructive symptoms. Digital rectal examination was normal. Trans-rectal ultrasound-guided biopsy revealed blue nevus in 4 out of 12 cores. Histology showed pigmented spindle cells in stroma confirmed by Fontana-Masson stain. Immunohistochemistry was positive for S100, HMB45, and Melan-A. No malignancy was seen.
Clinical Discussion:
Blue nevus may be confused with malignant melanoma, especially in the absence of clinical suspicion. Immunohistochemistry plays a vital role in differentiation. The lesion has excellent prognosis and requires no follow-up beyond routine screening.
Conclusion:
We present a case of multifocal PBN identified during evaluation for lower urinary tract symptoms. Awareness of this entity is crucial to avoid misdiagnosis and unnecessary interventions.
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