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Duplicate Prescription Patterns in Patients With Substance Use Disorders.

Johannes Heck1, Benjamin Krichevsky2,3, Martin Schulze Westhoff4

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|December 18, 2025
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Summary
This summary is machine-generated.

Potentially inappropriate duplicate prescriptions (PIDPs) occurred in 12.8% of psychiatric patients with substance use disorders. Sedatives and opioids were common causes, highlighting the need for careful medication monitoring to prevent adverse drug reactions.

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addiction psychiatrycross‐sectional studyduplicate prescriptionsmedication reviewpharmacotherapy safety

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Area of Science:

  • Pharmacology
  • Psychiatry
  • Health Services Research

Background:

  • Duplicate prescriptions (DPs) are a concern in patient care.
  • Classifying DPs into appropriate (ADPs) and potentially inappropriate (PIDPs) is crucial for evaluating medication safety.
  • Patients with substance use disorders (SUDs) often have complex medication regimens, increasing the risk of DPs.

Purpose of the Study:

  • To determine the frequency and characteristics of PIDPs in psychiatric inpatients with SUDs.
  • To differentiate between ADPs and PIDPs in this patient population.
  • To identify common drug classes associated with PIDPs.

Main Methods:

  • Retrospective cross-sectional study of 1174 patients at a university hospital's addiction ward.
  • Analysis of medication records from January 2016 to December 2021.
  • Classification of DPs into ADPs and PIDPs (grades 1-3).

Main Results:

  • 12.8% of patients experienced at least one PIDP.
  • Grade-1 PIDPs were most frequent (12.0%), primarily involving sedatives.
  • Grade-2 PIDPs (1.3%) were mainly associated with opioids.
  • 29.0% of patients had at least one ADP.

Conclusions:

  • Potentially inappropriate duplicate prescriptions are prevalent in psychiatric patients with SUDs.
  • Sedatives and opioids are key drug classes contributing to PIDPs.
  • Vigilant monitoring for PIDPs is essential to improve patient safety and reduce healthcare costs.