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Protein pattern or cerebrospinal fluid in spasmodic torticollis
Journal of Neurology, Neurosurgery, and Psychiatry
|October 1, 1974
Summary
Cerebrospinal fluid protein analysis revealed alkaline end fractions in the gamma-globulin region for patients with spasmodic torticollis. This finding may help differentiate organic from hysterical torticollis cases.
Area of Science:
- Neurology
- Biochemistry
- Proteomics
Background:
- Spasmodic torticollis is a neurological movement disorder.
- Cerebrospinal fluid (CSF) protein analysis can aid in diagnosing neurological conditions.
- Previous studies noted alkaline end fractions in CSF-gamma-globulin in other neurological diseases.
Purpose of the Study:
- To investigate the protein patterns in the cerebrospinal fluid of patients with spasmodic torticollis.
- To determine if specific protein fractions can help differentiate organic from hysterical torticollis.
Main Methods:
- Isoelectric focusing of cerebrospinal fluid.
- Quantitative paper electrophoresis of cerebrospinal fluid.
Main Results:
- Three patients with spasmodic torticollis exhibited very alkaline end fractions in the CSF-gamma-globulin region via isoelectric focusing.
- These alkaline end fractions share similar or identical isoelectric points with those observed in other extrapyramidal disorders and neurological diseases like multiple sclerosis and Huntington's chorea.
Conclusions:
- The presence of alkaline end fractions in the CSF-gamma-globulin region is a notable finding in spasmodic torticollis.
- Further research is needed to identify the exact composition of these fractions.
- CSF protein pattern analysis shows potential as a diagnostic tool for distinguishing between organic and hysterical forms of torticollis.