Related Experiment Video
Updated: Jan 8, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
1.0K
Prescribing Patterns in Pediatric Hidradenitis Suppurativa
Hannah Neimy1,2, Courtney L Walker3, Lara Wine Lee3
1College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Pediatric Dermatology
|December 18, 2025
Summary
Treatment for pediatric hidradenitis suppurativa (HS) varies by disease severity. More severe HS cases (Hurley stage III) received biologics, intralesional steroids, and pain management more frequently than milder cases (Hurley stage I).
Area of Science:
- Dermatology
- Pediatric Medicine
- Inflammatory Diseases
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- Increasing diagnosis rates in pediatric populations highlight a need for understanding treatment patterns.
- Limited data exists on HS treatment practices specifically in children and adolescents.
Purpose of the Study:
- To analyze treatment variations in pediatric hidradenitis suppurativa based on disease severity.
- To identify specific therapies more commonly used in severe pediatric HS cases.
Main Methods:
- Retrospective study analyzing data from 163 pediatric patients (age ≤ 18) diagnosed with HS.
- Comparison of treatment modalities across different Hurley stages (I, II, III) of the disease.
- Statistical analysis to determine significant differences in treatment patterns based on disease severity.
Main Results:
- Treatment patterns for pediatric HS significantly correlate with disease severity (Hurley stage).
- Patients with Hurley stage III HS were more likely to receive biologics, chlorhexidine, intralesional steroids, metformin, oral steroids, and spironolactone compared to Hurley stage I.
- Higher Hurley stages were associated with increased prescriptions for pain management, including NSAIDs and opioids.
Conclusions:
- Disease severity is a key determinant of treatment selection in pediatric hidradenitis suppurativa.
- More aggressive therapies and pain management are utilized in more severe pediatric HS cases.
- Further research is warranted to optimize HS management strategies in pediatric patients.
Related Concept Videos
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
194
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
194
01:23Hand hygiene
5.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
5.4K
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
230
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
230
01:29Drug Dosing: Infants and Children
231
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
231
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
174
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
174
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
240
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
240