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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Setmelanotide in Bardet-Biedl Syndrome: A Case Report.

Shelby Smith¹, Eric Sanfilippo², Lara Wine Lee^2,3

¹School of Medicine, University of South Carolina, Columbia, South Carolina, USA.

Pediatric Dermatology

|April 17, 2026

Summary

Setmelanotide, a treatment for Bardet-Biedl syndrome, can cause hyperpigmentation. Regular dermatologic screening is recommended to monitor for this and other potential side effects during treatment.

Area of Science:

Pharmacology
Dermatology
Genetics

Background:

Setmelanotide is a melanocortin-4-receptor agonist.
It is prescribed for hyperphagia associated with Bardet-Biedl syndrome.

Keywords:

Bardet‐Biedl syndrome MCR4 agonist melanoma risk setmelanotide skin cancer screening

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