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Updated: Jan 8, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
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Deep Eutectic Solvents in Chronic Wound Management: Current Developments and Future Prospects.

Rakesh Bastola1, Raj Kumar Thapa1,2

  • 1Pharmacy Program, Gandaki University, Pokhara, Kaski, Nepal.

International Journal of Nanomedicine
|December 18, 2025
PubMed
Summary
This summary is machine-generated.

Deep Eutectic Solvents (DESs) show promise for chronic wound healing by enhancing drug delivery and fighting infection. Their antimicrobial and antibiofilm properties offer new therapeutic strategies for complex wounds.

Keywords:
antibiofilm agentchronic wounddeep eutectic solventpenetration enhancerwound healing

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Wound Healing Research

Background:

  • Chronic wounds represent a significant global health burden, with infection being a primary impediment to healing.
  • Biofilms in chronic wounds disrupt the natural healing cascade, leading to persistent infections and increased healthcare costs.
  • Novel strategies for infection control and enhanced drug delivery are crucial for effective chronic wound management.

Purpose of the Study:

  • To review the fundamentals of Deep Eutectic Solvents (DESs) for chronic wound management.
  • To explore the dual role of DESs as penetration enhancers and antimicrobial/antibiofilm agents.
  • To discuss the potential and challenges of DESs in clinical applications for wound healing.

Main Methods:

  • Literature review focusing on Deep Eutectic Solvents (DESs) and their application in wound healing.
  • Analysis of DES properties including penetration enhancement, antimicrobial activity, and antibiofilm efficacy.
  • Summary of current research on DES-based formulations for infected wounds.

Main Results:

  • DESs possess multifunctional properties, acting as penetration enhancers to improve drug permeation.
  • DESs exhibit intrinsic antimicrobial and antibiofilm activities, crucial for combating wound infections.
  • Recent investigations show promising DES-based formulations for managing chronic infected wounds.

Conclusions:

  • DESs offer a versatile platform for developing advanced therapies for chronic wound management.
  • Their ability to enhance drug delivery and combat biofilms presents a novel approach to treating complex wounds.
  • Further research and clinical trials are needed to fully realize the potential of DESs in wound care.