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Incidence of and Risk Factors for Laryngopharyngeal Reflux in Patients Undergoing Modified Electroconvulsive Therapy:

Xingying Mo1, Xiaoyue Li2, Tingwei Zheng1

  • 1Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.

Therapeutics and Clinical Risk Management
|December 18, 2025
PubMed
Abstract

Insights

Laryngopharyngeal reflux (LPR) affects 39.3% of patients undergoing modified electroconvulsive therapy (MECT). Risk factors include acid regurgitation history, multiple MECT sessions, and higher succinylcholine doses.

Area of Science:

  • Neurology
  • Gastroenterology
  • Psychiatry

Background:

  • Laryngopharyngeal reflux (LPR) is a frequent complication of modified electroconvulsive therapy (MECT).
  • Understanding LPR prevalence and risk factors in MECT patients is crucial for patient care.

Purpose of the Study:

  • To determine the prevalence of LPR in patients undergoing MECT.
  • To identify independent risk factors associated with LPR development in this population.

Main Methods:

  • An observational prospective study included 107 consecutive patients undergoing MECT.
  • The salivary pepsin test was employed for LPR diagnosis.
  • Data on potential risk factors were systematically collected.

Main Results:

  • The incidence of LPR among MECT patients was 39.3%.
  • Multivariate analysis identified significant independent risk factors: >3 MECT sessions (OR 3.02), history of acid regurgitation (OR 3.90), succinylcholine dose > 50 mg (OR 2.54), and oral secretion volume > 3 mL (OR 3.66).

Conclusions:

  • A history of acid regurgitation, more than three MECT sessions, a succinylcholine dose exceeding 50 mg, and oral secretion volume greater than 3 mL are significantly associated with an increased risk of LPR in patients undergoing MECT.
Keywords:
LPRMECTrisk factorssalivary pepsin test

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