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Related Experiment Videos

[Ovulation induction by cyclofenil (author's transl)].

L Mettler, E Brandl, H Dahlen

    MMW, Munchener Medizinische Wochenschrift
    |December 2, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Cyclofenil effectively induces ovulation in women with irregular cycles, with a 42% ovulation rate observed. This fertility treatment shows promise for patients experiencing anovulatory cycles and amenorrhea.

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology

    Context:

    • Investigated the ovulation-inducing effects of cyclofenil in 135 women aged 20-35.
    • Included patients with documented anovulatory cycles over two consecutive periods.
    • Utilized multiple criteria including basal body temperature, cervical score, hormone levels (LH, progesterone), and urinary estrogens to confirm ovulation.

    Purpose:

    • To evaluate the efficacy of cyclofenil as an ovulation induction agent.
    • To determine the ovulation rate in women with and without amenorrhea.

    Summary:

    • Cyclofenil administration resulted in an overall ovulation rate of 42% across 241 observed cycles.
    • In patients with anovulatory cycles (n=114), the ovulation rate was 50% over 184 cycles.
    • Ovulation occurred in 6 out of 57 cycles (approximately 10.5%) in the 21 amenorrheic patients.

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  • Reported side effects were minimal, with nausea or vomiting in only 2 cases.

    • Impact:

    • Cyclofenil demonstrates potential as a therapeutic option for ovulation induction in women with anovulatory conditions.
    • Highlights the importance of comprehensive criteria for confirming ovulation in clinical trials.
    • Suggests further research into optimizing cyclofenil dosage and patient selection for improved fertility outcomes.