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Updated: Jan 7, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Immune biomarkers for head and neck cancer
Navid Sobhani1, Alberto D'Angelo2, Fernanda G Kugeratski3
1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. NSobhani@mdanderson.org.
Abstract:
In recent years, head and neck cancer therapy has been revolutionized by immunotherapy, which aims to restore the immune system's anticancer activity suppressed by cancer cells. The major concern is that only a subset of patients responds to this therapy. Having specific biomarkers that could help identify the patients who are most likely to benefit from immunotherapies would be extremely useful. This review first explains the current immunotherapies tested in head and neck cancer, to then delve into the current prognostic and predictive biomarkers that have been investigated in this field to predict their responses. In our opinion, a broader selection of biomarkers could further improve who will respond best to immunotherapy.
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