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Ergothioneine Depletion in Peritoneal Dialysis
Lindsey S Keo1,2, Josef K Suba1,2, Nhat M Pham3
1The Department of Medicine, Stanford University, Palo Alto, California.
Kidney360
|December 18, 2025
Summary
Dialysis patients have lower levels of the antioxidant ergothioneine. Peritoneal dialysis (PD) patients showed less depletion than hemodialysis (HD) patients, suggesting PD removes less ergothioneine.
Area of Science:
- Nephrology
- Nutritional Biochemistry
- Clinical Chemistry
Background:
- Dialysis treatments can deplete essential nutrients and antioxidants.
- Previous research indicated significant ergothioneine depletion in hemodialysis (HD) patients.
- Standard peritoneal dialysis (PD) offers lower small molecule clearance compared to HD.
Purpose of the Study:
- To investigate ergothioneine depletion in peritoneal dialysis (PD) patients.
- To compare the degree of ergothioneine depletion between PD and HD patients.
- To assess ergothioneine clearance in both PD and HD.
Main Methods:
- Compared plasma and erythrocyte ergothioneine levels in 16 PD patients, 16 HD patients, and 15 controls.
- Utilized liquid chromatography-mass spectrometry for ergothioneine quantification.
- Evaluated and compared ergothioneine clearances for PD and HD modalities.
Main Results:
- Erythrocyte ergothioneine levels were significantly lower in both PD and HD patients versus controls.
- PD patients exhibited less ergothioneine depletion (34% of controls) compared to HD patients (10% of controls).
- PD demonstrated lower time-averaged ergothioneine clearance than HD.
Conclusions:
- Ergothioneine, an antioxidant, is depleted in PD patients, though less severely than in HD patients.
- The reduced clearance with PD suggests less daily removal of ergothioneine.
- Further research is needed to determine the clinical benefits of ergothioneine supplementation in dialysis patients.
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