Research on hemorrhagic stroke detection enhanced by magnetic nanoparticle-based magnetic induction

Objective.Prompt identification of haematomas is crucial for effective clinical treatment. Magnetic induction phase shift technology (MIPS), known for its portability, non-contact nature, and affordability, is limited by the weak signal induced by cerebral hemorrhage leading to poor sensitivity, which is urgent to be improved.Approach. Tracer of magnetic nanoparticles is introduced to produce robust induced magnetic field. A symmetrical gradiometer coil is used as the receiving coil to nullify the effect of primary magnetic field generated by the excitation coil, which is designed as a Helmholtz coil.Main results.In vitroexperiments showcase the remarkably improved sensitivity and stability of the detection system, with magnetic nanoparticles notably boosting the MIPS signal for hemorrhage. Moreover,in vivoexperiments employing a rabbit autologous blood cerebral hemorrhage model reveal that with a hemorrhage volume of 2 ml, the experimental group with employed magnetic nanoparticles increased the MIPS signal change by 23-fold compared to the control group without magnetic nanoparticles.Significance. The sensitivity of MIPS for hemorrhage detection is significantly improved compared to traditional method. The magnetic nanoparticle-enhanced MIPS detection technique holds promise as an optimal solution for real-time, non-invasive bedside monitoring for cerebral hemorrhage.