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Updated: Jan 8, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
Circadian clock genes: Potential therapeutic targets for autoimmune diseases
Tian Tian1, Lulu Rao2, Mengzhu Wei2
1School of Pharmacy and Science, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, 230032, China; MOE Key Laboratory of Population Health Across Life Cycle / Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Hefei, 230032, China.
None:
Circadian rhythms are endogenous 24-h oscillations in physiological processes, with their regulation dependent on a molecular network comprising the core clock genes (CLOCK, BMAL1, PER, CRY) and other key clock genes (NR1D1/2, RORs). Research indicates that circadian rhythm disruption is a significant risk factor for immune dysregulation, while maintaining circadian rhythm balance may offer new therapeutic avenues for autoimmune diseases. This review systematically examines the regulatory mechanisms of the circadian clock genes in innate immunity, adaptive immunity (particularly Th17 cell differentiation and function), and inflammatory responses. By elucidating their molecular interactions, it clarifies the pivotal role of these clock genes in autoimmune diseases. Additionally, we have summarized research progress on small molecule modulators targeting clock genes, as well as non-pharmacological interventions such as sleep regulation, intermittent fasting (IF)/time-restricted feeding (TRF), and melatonin supplementation.In summary, this review aims to elucidate the role of clock genes in immune regulation and inflammatory responses, emphasizing their potential as therapeutic targets for autoimmune diseases.
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