Calcified chondroid mesenchymal neoplasm

Calcified chondroid mesenchymal neoplasm (CCMN) is a recently described benign matrix-forming soft tissue tumor with a predilection for the distal extremities and the temporomandibular joint (TMJ) of adults which frequently harbors FN1 fusions. Since its initial description in 2021, nearly 100 CCMNs have been reported thus broadening its clinicopathologic and molecular genetic spectrum in recent years. This manuscript will discuss, in detail, our current understanding of CCMN including a historical review of morphologically similar entities, as well as provide pertinent differential diagnoses of CCMN with a specific focus on tumors arising within the head and neck region.