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The first pediatric case successfully treated with cefiderocol for IMP-type carbapenemase-producing Enterobacterales

Haruna Mori1, Yuto Otsubo2, Meiwa Shibata2

  • 1Division of Neonatology, Department of Intensive Care, Tokyo Metropolitan Children's Medical Center, 2-8-29 Musashidai, Fuchu, Tokyo, 183-8561, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|December 18, 2025
PubMed

Insights

This is the first pediatric case of successful cefiderocol treatment for carbapenemase-producing Enterobacterales (CPE) bacteremia caused by IMP-type Klebsiella pneumoniae. The antibiotic combination therapy effectively cleared the infection in a young patient.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Antimicrobial Resistance

Background:

  • Carbapenemase-producing Enterobacterales (CPE) pose a significant global health threat.
  • Cefiderocol demonstrates in vitro activity against various CPE, but clinical data, especially in pediatric populations, is limited for IMP-type CPE.
  • IMP-type CPE infections are challenging to treat due to limited therapeutic options.

Keywords:
Carbapenemase-producing EnterobacteralesCefiderocol

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