Gas Plasma-Derived Reactive Species for Oxidative and Biomaterial Modifications-Smart Chemistry Enabling Biomedical...

Area of Science:

• Biomedical Engineering
• Materials Science
• Plasma Physics

Background:

• Cold gas plasma generates reactive oxygen and nitrogen species (ROS/RNS).
• ROS/RNS interact with materials and biological systems, altering physicochemical properties and cellular processes.
• Plasma can modify materials or act as a biological stimulus/co-therapeutic.

Purpose of the Study:

• Review recent advances in plasma-induced chemical transformations.
• Discuss the dual role of plasma in molecular engineering and co-therapy.
• Highlight future directions for plasma technologies in biomedicine.

Main Methods:

• Literature review of plasma chemistry in biological and medical applications.
• Analysis of plasma-material interactions.
• Examination of plasma's biological effects on cells and tissues.

Main Results:

• Plasma-derived reactive species modify material surfaces (hydrogels, scaffolds, nanomaterials).
• Reactive species interact with biomolecules and cellular pathways, modulating redox signaling, immune responses, and metabolism.
• Plasma serves as both a material engineering platform and a co-therapeutic agent.

Conclusions:

• Spatiotemporal control of ROS/RNS is crucial for next-generation functional materials.
• Plasma enables in situ cellular programming by modulating signaling pathways and tissue microenvironments.
• Plasma technologies offer promising capabilities for scaffold activation, antimicrobial/antitumor actions, and precision tissue regeneration.