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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
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A Rare Case Report-an Early-Stage Invasive Lobular Carcinoma with Her 2 Neu Positivity
Preeti Grewal1, Geeta Kadayaprath2, Parul Sobti3
1Breast Surgical Oncology, Indraprastha Apollo Hospitals, New Delhi, India.
Indian Journal of Surgical Oncology
|December 19, 2025
Summary
Invasive lobular breast cancer (ILC) is a rare subtype. This case report details an early-stage ILC with hormone receptor and HER2 positivity, highlighting a rare presentation.
Area of Science:
- Oncology
- Pathology
Background:
- Invasive lobular breast cancer (ILC) is a distinct subtype with unique morphology and clinical behavior.
- ILC accounts for 5-15% of invasive breast cancers.
- HER2 positivity in ILC is rare and associated with adverse outcomes, though literature is limited.
Purpose of the Study:
- To report a case of early-stage invasive lobular breast cancer with hormone receptor and HER2 positivity.
- To contribute to the limited literature on HER2-positive ILC.
Main Methods:
- Case report presentation.
- Review of clinical and pathological data for an early-stage ILC patient.
Main Results:
- The patient presented with early-stage invasive lobular breast cancer.
- The tumor was positive for both hormone receptors and HER2.
- Management followed standard multimodality breast cancer guidelines.
Conclusions:
- Early-stage invasive lobular breast cancer with hormone receptor and HER2 positivity is a rare clinical scenario.
- Standard breast cancer management guidelines are applicable.
- Further research is needed to understand the implications of HER2 positivity in ILC.
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