Factors Predicting Pathological Complete Response and Survival Outcomes in Breast Cancer Patients Receiving...

Area of Science:

• Oncology
• Breast Cancer Research
• Chemotherapy

Background:

• Neoadjuvant chemotherapy (NACT) is a standard treatment for specific breast cancer types.
• NACT aims to improve operability and systemic control.
• Identifying factors influencing treatment response and survival is crucial.

Purpose of the Study:

• To identify risk factors for failing to achieve pathological complete response (pCR) after NACT.
• To examine factors predicting survival outcomes in breast cancer patients receiving NACT.

Main Methods:

• Retrospective analysis of 224 breast cancer patients treated with NACT (2010-2020).
• Evaluation of hormone receptor (HR) status, HER2 amplification, biological subtype, disease stage, molecular type, and histological type.
• Correlation of these factors with pCR achievement and overall survival.

Main Results:

• 65 out of 224 patients achieved pCR.
• HR status, HER2 amplification, and biological subtype significantly impacted pCR rates.
• Disease stage, molecular type, and histological type predicted overall survival in patients achieving pCR.
• Early-stage disease, luminal subtype, and invasive mammary carcinoma of no special type (NST) were linked to favorable prognosis.

Conclusions:

• Breast cancer characteristics like HR status, HER2 amplification, and subtype are key determinants of pCR following NACT.
• Prognosis after NACT is influenced by disease stage, molecular, and histological subtypes.
• Further research can refine NACT strategies based on these predictive factors.